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Bariatric Surgery Helps Forestall Gout

Compare Affordable Adjustable Gastric band Surgery overseas Best Cost gastric bypass surgery Weight loss surgery Helps Forestall Gout Obese individuals who experienced weight loss surgery stood a 34 CI .53-.82, P<0.001), the researchers reported online in Annals of the Rheumatic Diseases. "The beneficial effects of bariatric surgery are not limited to weight loss , but they extend to improvement in metabolic parameters and to lower risk of developing type 2 diabetes, cardiovascular disease, and cancer," the team wrote. Studies have also suggested that bariatric surgery can lower serum uric acid levels, and one report suggested that there might be a short-term decrease in attacks among patients with gout. To assess the long-term effects of the surgery on incident gout among obese individuals without gout at baseline, the researchers analyzed data from the prospective interventional Swedish Obese Subjects (SOS) study, which recruited 4,047 individuals from 1987 to 2001. Among these, 2,010 had the surgery, while the remainder represented controls, who were matched for multiple factors including age, sex, height, weight, waist and hip circumference, blood pressure, cholesterol, smoking, and psychosocial variables. The surgical procedures were vertical banded gastroplasty in 1,369, gastric banding in 376, and gastric bypass in 265. Among controls, management strategies included anti-obesity drug treatment and intensive lifestyle modification involving advice on food choices, energy intake, and exercise. The primary endpoint of the SOS study had been mortality the effect on gout was a post-hoc analysis. Hyperuricemia was defined as serum uric acid levels of 6.8 mg/dL or higher. Patients in the surgery group were younger than the controls (age 47 versus 49, P<0.001), and had higher body mass index (BMI), greater waist circumference, and worse metabolic factors such as glucose levels and cholesterol. Those in the surgery group also more often had diabetes and hypertension, but uric acid levels were similar, at 5.9 to 6 mg/dL. Among controls, 23 of the surgery group (P=0.11). At 2 years, BMI had fallen by 23 CI -24 to -23) among patients in the surgery group, while there was no change in the control group ( 0.1 CI -0.3 to 0.5), which was a significant intergroup difference (P<0.001). By 10 years, changes in BMI were -17 CI -17 to -16) in the surgery group and 2 CI 1-2) among controls (P<0.001). At 15 years, the difference in absolute risk between the surgery and control groups was three percentage points, and the number needed to treat was 32 (95 CI 0.48-0.75, P<0.001). Individual factors associated with an adjusted higher risk were: Age (per 10 years), HR 1.81 (95 CI 2.28-15.5, P<0.001) Uric acid =6.8 mg/dL, HR 3.67 (95 CI 1.03-1.97, P=0.03) Type 2 diabetes, HR 1.56 (95 CI 1.08-1.78, P=0.01) and Alcohol intake (per 1 g/day), HR 1.02 (95 lower incidence, with an unadjusted hazard ratio of 0.51 (95% CI 0.43-0.62,Read more…

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