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Selective Antagonism of Muscarinic Receptors Is Neuroprotective in Peripheral Neuropathy.

Research ArticleNeuroscience Free access | 10.1172/JCI88321 Nigel A. Calcutt,1 Darrell R. Smith,2 Katie Frizzi,1 Mohammad Golam Sabbir,2 Subir K. Roy Chowdhury,2 Teresa Mixcoatl-Zecuatl,1 Ali Saleh,2 Nabeel Muttalib,1 Randy Van der Ploeg,2 Joseline Ochoa,1 Allison Gopaul,1 Lori Tessler,2 Jürgen Wess,3 Corinne G. Jolivalt,1 and Paul Fernyhough2,4 1Department of Pathology, UCSD, La Jolla, California, USA. 2Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada. 3Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA. 4Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. Address correspondence to: Paul Fernyhough, R4046 – 351 Taché Avenue, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, R2H 2A6, Canada. Phone: 204.235.3692; E-mail: pfernyhough@sbrc.ca. Find articles by Calcutt, N. in: JCI | PubMed | Google Scholar 1Department of Pathology, UCSD, La Jolla, California, USA. 2Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada. 3Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA. 4Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. Address correspondence to: Paul Fernyhough, R4046 – 351 Taché Avenue, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, R2H 2A6, Canada. Phone: 204.235.3692; E-mail: pfernyhough@sbrc.ca. Find articles by Smith, D. in: JCI | PubMed | Google Scholar 1Department of Pathology, UCSD, La Jolla, California, USA. 2Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada. 3Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA. 4Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. Address correspondence to: Paul Fernyhough, R4046 – 351 Taché Avenue, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, R2H 2A6, Canada. Phone: 204.235.3692; E-mail: pfernyhough@sbrc.ca. Find articles by Frizzi, K. in: JCI | PubMed | Google Scholar 1Department of Pathology, UCSD, La Jolla, California, USA. 2Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada. 3Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA. 4Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. Address correspondence to: Paul Fernyhough, R4046 – 351 Taché Avenue, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, R2H 2A6, Canada. Phone: 204.235.3692; E-mail: pfernyhough@sbrc.ca. Find articles by Sabbir, M. in: JCI | PubMed | Google Scholar 1Department of Pathology, UCSD, La Jolla, California, USA. 2Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada. 3Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, NIH, Bethesda, Maryland, USA. 4Department of Pharmacology and Therapeutics, University of Manitoba, Winnipeg, Manitoba, Canada. Address correspondence to: Paul Fernyhough, R4046 – 351 Taché Avenue, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, R2H 2A6, Canada. Phone: 204.235.3692; E-mail: pfernyhough@sbrc.ca. Find articles by Chowdhury, S. in: JCI | PubMed | Google Scholar 1Department of Pathology, UCSD, La Jolla, California, USA. 2Division of Neurodegenerative Disorders, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada. 3Molecular Signaling Section, LaboratoryRead more…

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